In The Politics of Autism, I discuss various ideas about what causes the condition.
Allison Parshall at Scientific American:
[In] the 1970s studies of twins revealed that autism is highly heritable, not something that develops after birth. Thus began the search for the genes responsible. “We had rather simple views about what it might be” that caused autism, says Helen Tager-Flusberg, a professor emerita at Boston University. The idea in the 1990s, she recalls, was that “we’re talking about six to 10 genes.” Instead researchers found hundreds.
No simple theory of autism has ever panned out, and the scientific community has moved on from the search for a simple answer. Researchers now know that autism develops from a staggeringly complex interplay between genes and factors that can influence development in utero. But attempts to pin the condition on one root cause abound, most famously in the disproven idea that vaccines cause autism. And earlier this year U.S. Secretary of Health and Human Services Robert F. Kennedy, Jr., announced that he will reveal the “interventions” that are “almost certainly causing autism” in September.
...
Untangling genetic factors from nongenetic ones (which scientists call “environmental factors”) can be tricky. For example, studies have consistently shown that parental age at conception can play a role, with older parents being more likely to have autistic children. But that could be because of the effect of age on genes: people accumulate mutations with age and can pass these on to their kids. Other factors that have been linked to autism include people being bornprematurely or through cesareansection, as well as pregnant people having obesity, using certain medications (such as the antiseizure drug valproate) and the pain reliever acetaminophen (the active ingredient in Tylenol) and being exposed to air pollution. The strength of the evidence for these links varies, though, and the increases in risk tend to be small. The evidence is also only correlational, meaning it can’t establish what caused what.
...
A large portion of autism research funding has gone toward searching for causes of the condition. And while this research is crucial, it seems unlikely to improve the lives of autistic people and their loved ones in the short term.
“The average autistic person, or their average family member, doesn't wake up in the morning thinking, ‘Oh, have they discovered a better mouse model [for simulating autism in laboratory research]?’” explains Ari Ne’eman, co-founder of the Autistic Self Advocacy Network and a health policy researcher at Harvard University. What autistic people and their loved ones most need is research into kinds of support that effectively address their day-to-day needs. A rebalancing of our research priorities, he says, is “long overdue.”
